Recombinant Human Cathepsin S (CTSS)

The Human CTSS protein's gene (115-331aa) is inserted into a plasmid vector, forming recombinant plasmid, which is introduced into e.coli cells. e.coli cells surviving in the presence of a specific antibiotic are selected and then cultured under conditions promoting the expression of the gene of interest. The protein features a N-terminal 6xHis tag fusion. After expression, the recombinant Human CTSS protein is isolated and purified from the cell lysate through affinity purification. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant protein, revealing a purity exceeding 90%.

ACP02879

The Human CTSS protein’s gene (115-331aa) is inserted into a plasmid vector, forming recombinant plasmid, which is introduced into e.coli cells. e.coli cells surviving in the presence of a specific antibiotic are selected and then cultured under conditions promoting the expression of the gene of interest. The protein features a N-terminal 6xHis tag fusion. After expression, the recombinant Human CTSS protein is isolated and purified from the cell lysate through affinity purification. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant protein, revealing a purity exceeding 90%.

Number

Cat.No	ACP02879	Target Name	Ctss
Target Synonyms	Cathepsin S; CathepsinS; CATS_HUMAN; Ctss	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	115-331aa
Mol Weight	28.0kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02879

Target Name

Ctss

Target Synonyms

Cathepsin S; CathepsinS; CATS_HUMAN; Ctss

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

115-331aa

Mol Weight

28.0kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P25774

Background Information

Uniprot Id

P25774
Target Species

Human
Target Name

CTSS
Target Full Name

Cathepsin S
Target Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Target Subcellular Location

Lysosome. Secreted. Cytoplasmic vesicle, phagosome.
Target Protein Families

Peptidase C1 family
Target Research Area

Immunology
Target Synonyms

Cathepsin S; CathepsinS; CATS_HUMAN; Ctss
Target Background

The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Recombinant Human Cathepsin S (CTSS)

Specifications

Immunogen Information

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