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| Cat.No | ACP21130 | Target Name | CTIF |
|---|---|---|---|
| Target Synonyms | CTIF; KIAA0427; CBP80/20-dependent translation initiation factor | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-598 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43310 |
|---|
Uniprot Id
O43310
Target Species
Human
Target Name
CTIF
Target Full Name
CBP80/20-dependent translation initiation factor
Target Function
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD)
Target Subcellular Location
Cytoplasm, perinuclear region.
Target Protein Families
CTIF family
Target Tissue Specificity
Widely expressed.
Target Synonyms
CTIF; KIAA0427; CBP80/20-dependent translation initiation factor
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