Recombinant Human CCAAT/enhancer-binding protein epsilon (CEBPE)

Uniprot Id

Q15744

Target Species

Human

Target Name

CEBPE

Target Full Name

CCAAT/enhancer-binding protein epsilon

Target Function

Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.

Target Involvement

Specific granule deficiency 1 (SGD1)

Target Subcellular Location

Nucleus.

Target Protein Families

BZIP family, C/EBP subfamily

Target Tissue Specificity

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Target Synonyms

C/EBP epsilon; CCAAT/enhancer binding protein (C/EBP) epsilon; CCAAT/enhancer binding protein epsilon; CCAAT/enhancer-binding protein epsilon; CEBPE; CEBPE_HUMAN; CRP 1; CRP1

Target Background

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.