Recombinant Human Chromosome-associated kinesin KIF4A (KIF4A), Truncated

Uniprot Id

O95239

Target Species

Human

Target Name

KIF4A

Target Full Name

Chromosome-associated kinesin KIF4A

Target Function

Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.

Target Subcellular Location

Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily

Target Tissue Specificity

Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.

Target Synonyms

Chromokinesin; Chromokinesin-A; Chromosome associated kinesin KIF4A; Chromosome-associated kinesin KIF4A; FLJ12530; FLJ12655; FLJ14204; FLJ20631; HSA271784; KIF4; KIF4 G1; KIF4A; KIF4A_HUMAN; KIF4G1; Kinesin family member 4A

Target Background

This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.