Recombinant Human Ciliary neurotrophic factor (CNTF)

Uniprot Id

P26441

Target Species

Human

Target Name

CNTF

Target Full Name

Ciliary neurotrophic factor

Target Function

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

Target Subcellular Location

Cytoplasm.

Target Protein Families

CNTF family

Target Tissue Specificity

Nervous system.

Target Research Area

Neuroscience, Developmental Biology

Target Synonyms

Ciliary neurotrophic factor; CNTF; CNTF_HUMAN; HCNTF

Target Background

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.