Recombinant Human Coagulation factor VII (F7), Truncated

Cat.No	ACP04721	Target Name	F7
Form	Liquid or Lyophilized powder	Expression System	Yeast
Expression Range	61-212aa	Mol Weight	19.0 kDa
Protein Length	Partial	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04721

Target Name

Form

Liquid or Lyophilized powder

Expression System

Yeast

Expression Range

61-212aa

Mol Weight

19.0 kDa

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P08709

Background Information

Uniprot Id

P08709
Target Species

Human
Target Name

F7
Target Full Name

Coagulation factor VII
Target Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Target Involvement

Factor VII deficiency (FA7D)
Target Subcellular Location

Secreted.
Target Protein Families

Peptidase S1 family
Target Tissue Specificity

Plasma.
Target Research Area

Cardiovascular
Target Synonyms

coagulation factor VII (serum prothrombin conversion accelerator); Coagulation factor VII; Eptacog alfa ; F7; FA7_HUMAN; Factor VII ; Factor VII heavy chain; Factor VII light chain; FVII coagulation protein ; OTTHUMP00000018733; OTTHUMP00000018734; Proconvertin; Serum prothrombin conversion accelerator; SPCA
Target Background

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Recombinant Human Coagulation factor VII (F7), Truncated

Specifications

Immunogen Information

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