Recombinant Human Cohesin subunit SA-2 (STAG2), Truncated

Uniprot Id

Q8N3U4

Target Species

Human

Target Name

STAG2

Target Full Name

Cohesin subunit SA-2

Target Function

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Target Subcellular Location

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

Target Protein Families

SCC3 family

Target Synonyms

bA517O1.1; Cohesin Subunit SA 2; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; FLJ25871; SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; STAG 2; stag2; STAG2_HUMAN; Stromal antigen 2