Recombinant Human Colipase (CLPS)

Uniprot Id

P04118

Target Species

Human

Target Name

CLPS

Target Full Name

Colipase

Target Function

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.; Enterostatin has a biological activity as a satiety signal.

Target Subcellular Location

Secreted.

Target Protein Families

Colipase family

Target Tissue Specificity

Expressed by the pancreas.

Target Synonyms

clpS; COL_HUMAN; Colipase; Colipase pancreatic; Pancreatic colipase preproprotein

Target Background

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene.