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The recombinant Human COL4A2 was expressed with the amino acid range of 1493-1712. This COL4A2 protein is theoretically predicted to have a molecular weight of 28.3 kDa. This COL4A2 protein is produced using e.coli expression system. The COL4A2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant COL4A2 protein during the following stages.The human collagen alpha-2 (IV) chain, encoded by the COL4A2 gene, is a vital component of type IV collagen, a major structural protein found in basement membranes. COL4A2 is essential for maintaining the structural integrity of tissues and organs, especially in the vascular system and basement membranes of various organs. Mutations in COL4A2 can lead to Alport syndrome, a hereditary disorder affecting the kidneys, eyes, and ears. Research on COL4A2 encompasses understanding its role in basement membrane function, tissue development, and its association with various pathological conditions. Investigating COL4A2 provides insights into extracellular matrix biology and has implications for potential therapeutic strategies targeting collagen-related disorders.
The recombinant Human COL4A2 was expressed with the amino acid range of 1493-1712. This COL4A2 protein is theoretically predicted to have a molecular weight of 28.3 kDa. This COL4A2 protein is produced using e.coli expression system. The COL4A2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant COL4A2 protein during the following stages.The human collagen alpha-2 (IV) chain, encoded by the COL4A2 gene, is a vital component of type IV collagen, a major structural protein found in basement membranes. COL4A2 is essential for maintaining the structural integrity of tissues and organs, especially in the vascular system and basement membranes of various organs. Mutations in COL4A2 can lead to Alport syndrome, a hereditary disorder affecting the kidneys, eyes, and ears. Research on COL4A2 encompasses understanding its role in basement membrane function, tissue development, and its association with various pathological conditions. Investigating COL4A2 provides insights into extracellular matrix biology and has implications for potential therapeutic strategies targeting collagen-related disorders.
| Cat.No | ACP02281 | Target Name | COL4A2 |
|---|---|---|---|
| Target Synonyms | Canstatin; CO4A2_HUMAN; COL4A 2; Col4a2; Collagen alpha 2(IV) chain; Collagen; type IV; alpha 2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1493-1712aa |
| Mol Weight | 28.3kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08572 |
|---|
Uniprot Id
P08572
Target Species
Human
Target Name
COL4A2
Target Full Name
Collagen alpha-2(IV) chain
Target Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Target Involvement
Porencephaly 2 (POREN2); Intracerebral hemorrhage (ICH)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Target Protein Families
Type IV collagen family
Target Research Area
Cancer
Target Synonyms
Canstatin; CO4A2_HUMAN; COL4A 2; Col4a2; Collagen alpha 2(IV) chain; Collagen; type IV; alpha 2
Target Background
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
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