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| Cat.No | ACP01367 | Target Name | COMMD5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 2-224aa | Mol Weight | 29.5 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9GZQ3 |
|---|
Uniprot Id
Q9GZQ3
Target Species
Human
Target Name
COMMD5
Target Full Name
COMM domain-containing protein 5
Target Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Tissue Specificity
Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
Target Research Area
Transcription
Target Synonyms
COMMD5; HT002COMM domain-containing protein 5; Hypertension-related calcium-regulated gene protein; HCaRG
Target Background
Predicted to be involved in proximal tubule morphogenesis. Located in cytosol and nucleoplasm.
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