Recombinant Human Contactin-associated protein 1 (CNTNAP1), Truncated

Uniprot Id

P78357

Target Species

Human

Target Name

CNTNAP1

Target Full Name

Contactin-associated protein 1

Target Function

Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.

Target Involvement

Lethal congenital contracture syndrome 7 (LCCS7)

Target Subcellular Location

Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.

Target Protein Families

Neurexin family

Target Tissue Specificity

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Target Research Area

Neuroscience

Target Synonyms

Caspr; Caspr1; CNTNAP; Cntnap1; CNTP1_HUMAN; Contactin associated protein 1; Contactin-associated protein 1; MHDNIV; NCP1; Neurexin 4; Neurexin IV; Neurexin-4; Nrxn4; p190; Paranodin

Target Background

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.