Recombinant Human Corticoliberin (CRH)

Uniprot Id

P06850

Target Species

Human

Target Name

CRH

Target Full Name

Corticoliberin

Target Function

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.

Target Subcellular Location

Secreted.

Target Protein Families

Sauvagine/corticotropin-releasing factor/urotensin I family

Target Tissue Specificity

Produced by the hypothalamus and placenta.

Target Synonyms

CRHCorticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone

Target Background

This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.