Recombinant Human Cystatin-SA (CST2)

Uniprot Id

P09228

Target Species

Human

Target Name

CST2

Target Full Name

Cystatin-SA

Target Function

Thiol protease inhibitor.

Target Subcellular Location

Secreted.

Target Protein Families

Cystatin family

Target Tissue Specificity

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in submandibular gland and parotid gland.

Target Synonyms

CST 2; CST2; Cystatin 2; Cystatin S5; Cystatin-2; Cystatin-S5; Cystatin-SA; Cysteine proteinase inhibitor; CYTT_HUMAN; MGC71924; Salivary cysteine (thiol) protease inhibitor

Target Background

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.