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The recombinant Human CYP11B2 was expressed with the amino acid range of 25-503. The calculated molecular weight for this CYP11B2 protein is 71 kDa. This CYP11B2 protein is produced using e.coli expression system. The CYP11B2 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CYP11B2 protein during the following stages.Human cytochrome P450 11B2 (CYP11B2) is a mitochondrial enzyme crucial for aldosterone biosynthesis in the adrenal glands. CYP11B2 catalyzes the final steps in the synthesis of aldosterone, a mineralocorticoid hormone that regulates electrolyte and fluid balance by acting on the kidneys. Aldosterone, in turn, plays a key role in maintaining blood pressure and electrolyte homeostasis by promoting sodium retention and potassium excretion in the kidneys. Dysfunction of CYP11B2 can lead to disorders such as hyperaldosteronism, impacting blood pressure regulation. Research on CYP11B2 contributes to understanding adrenal steroidogenesis and potential therapeutic targets for related conditions.
The recombinant Human CYP11B2 was expressed with the amino acid range of 25-503. The calculated molecular weight for this CYP11B2 protein is 71 kDa. This CYP11B2 protein is produced using e.coli expression system. The CYP11B2 gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CYP11B2 protein during the following stages.Human cytochrome P450 11B2 (CYP11B2) is a mitochondrial enzyme crucial for aldosterone biosynthesis in the adrenal glands. CYP11B2 catalyzes the final steps in the synthesis of aldosterone, a mineralocorticoid hormone that regulates electrolyte and fluid balance by acting on the kidneys. Aldosterone, in turn, plays a key role in maintaining blood pressure and electrolyte homeostasis by promoting sodium retention and potassium excretion in the kidneys. Dysfunction of CYP11B2 can lead to disorders such as hyperaldosteronism, impacting blood pressure regulation. Research on CYP11B2 contributes to understanding adrenal steroidogenesis and potential therapeutic targets for related conditions.
| Cat.No | ACP02344 | Target Name | CYP11B2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 25-503 | Mol Weight | 71.0kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P19099 |
|---|
Uniprot Id
P19099
Target Species
Human
Target Name
CYP11B2
Target Full Name
Cytochrome P450 11B2, mitochondrial
Target Function
A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Target Involvement
Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency); Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency); Hyperaldosteronism, familial, 1 (HALD1)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Research Area
others
Target Synonyms
ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2_HUMAN; CYP11B2; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2; Cytochrome P450 11B2; mitochondrial; mitochondrial; P-450Aldo; P-450C18; Steroid 18-hydroxylase
Target Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
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