Recombinant Human Cytokine receptor common subunit gamma (IL2RG), Truncated

Uniprot Id

P31785

Target Species

Human

Target Name

IL2RG

Target Full Name

Cytokine receptor common subunit gamma

Target Function

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.

Target Involvement

Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID); X-linked combined immunodeficiency (XCID)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell surface.

Target Protein Families

Type I cytokine receptor family, Type 5 subfamily

Target Research Area

Cancer

Target Synonyms

IL2RG; Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD antigen CD132

Target Background

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.