Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)

Uniprot Id

Q17RY0

Target Species

Human

Target Name

CPEB4

Target Full Name

Cytoplasmic polyadenylation element-binding protein 4

Target Function

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.

Target Subcellular Location

Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.

Target Protein Families

RRM CPEB family

Target Tissue Specificity

Expressed in pancreas in islets and ductal cells (at protein level). Expressed in melanocytes.

Target Synonyms

CPE binding protein 4; CPE-binding protein 4; CPE-BP4; cpeb4; CPEB4_HUMAN; Cytoplasmic polyadenylation element binding protein 4; Cytoplasmic polyadenylation element-binding protein 4; hCPEB-4; KIAA1673