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Recombinant Human Dachshund homolog 2 (DACH2)

ACP14052

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Specifications

Cat.No	ACP14052	Target Name	DACH2
Target Synonyms	DACH 2; Dach2; DACH2_HUMAN; Dachshund 2; Dachshund homolog 2 (Drosophila); Dachshund homolog 2; Dachshund2; FLJ31391 ; HGNC:16814; MGC138545	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-599
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96NX9

Background Information

Uniprot Id

Q96NX9
Target Species

Human
Target Name

DACH2
Target Full Name

Dachshund homolog 2
Target Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain.
Target Subcellular Location

Nucleus.
Target Protein Families

DACH/dachshund family
Target Synonyms

DACH 2; Dach2; DACH2_HUMAN; Dachshund 2; Dachshund homolog 2 (Drosophila); Dachshund homolog 2; Dachshund2; FLJ31391 ; HGNC:16814; MGC138545

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Recombinant Human Dachshund homolog 2 (DACH2)

Specifications

Immunogen Information

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