Recombinant Human Deoxyribonucleoside 5′-monophosphate N-glycosidase (RCL)

Uniprot Id

O43598

Target Species

Human

Target Name

DNPH1

Target Full Name

5-hydroxymethyl-dUMP N-hydrolase

Target Function

Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family

Target Tissue Specificity

Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers.

Target Synonyms

2' deoxynucleoside 5' phosphate N hydrolase 1; BC048355; c Myc responsive; c Myc responsive protein Rcl; c-Myc-responsive protein Rcl; C6orf108; C76683; Chromosome 6 open reading frame 108; Deoxyribonucleoside 5' monophosphate N glycosidase; Deoxyribonucleoside 5''-monophosphate N-glycosidase; dJ330M21.3; DNPH1; MGC54855; Putative c Myc responsive; Rcl; RCL_HUMAN; RP3 330M21.3

Target Background

This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described.