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The expression region of this recombinant Human DCD covers amino acids 20-110. The theoretical molecular weight of the DCD protein is 36.3 kDa. This DCD protein is produced using e.coli expression system. The DCD gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant DCD protein during the following stages.Dermcidin (DCD) is a human antimicrobial peptide with a broad-spectrum role in the innate immune system. It is primarily produced in eccrine sweat glands and secreted into sweat, saliva, and other bodily fluids. Dermcidin exhibits potent antimicrobial properties, particularly against bacteria, fungi, and certain viruses. By disrupting microbial membranes and inhibiting bacterial growth, dermcidin plays a crucial role in protecting the skin and mucous membranes from pathogenic infections. Additionally, dermcidin's involvement in immune responses and its potential as an antimicrobial therapeutic agent make it a subject of interest in research related to infectious diseases and dermatological conditions. Understanding dermcidin's functions contributes to insights into host defense mechanisms and the development of novel antimicrobial strategies.
The expression region of this recombinant Human DCD covers amino acids 20-110. The theoretical molecular weight of the DCD protein is 36.3 kDa. This DCD protein is produced using e.coli expression system. The DCD gene fragment has been modified by fusing the N-terminal GST tag, providing convenience in detecting and purifying the recombinant DCD protein during the following stages.Dermcidin (DCD) is a human antimicrobial peptide with a broad-spectrum role in the innate immune system. It is primarily produced in eccrine sweat glands and secreted into sweat, saliva, and other bodily fluids. Dermcidin exhibits potent antimicrobial properties, particularly against bacteria, fungi, and certain viruses. By disrupting microbial membranes and inhibiting bacterial growth, dermcidin plays a crucial role in protecting the skin and mucous membranes from pathogenic infections. Additionally, dermcidin’s involvement in immune responses and its potential as an antimicrobial therapeutic agent make it a subject of interest in research related to infectious diseases and dermatological conditions. Understanding dermcidin’s functions contributes to insights into host defense mechanisms and the development of novel antimicrobial strategies.
| Cat.No | ACP03123 | Target Name | DCD |
|---|---|---|---|
| Target Synonyms | AIDD ; DCD 1; dcd; DCD-1; DCD_HUMAN; Dermcidin; DSEP; HCAP; PIF; Preproteolysin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 20-110aa |
| Mol Weight | 36.3kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P81605 |
|---|
Uniprot Id
P81605
Target Species
Human
Target Name
DCD
Target Full Name
Dermcidin
Target Function
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues.; Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Target Subcellular Location
Secreted.
Target Tissue Specificity
Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
Target Research Area
Signal Transduction
Target Synonyms
AIDD ; DCD 1; dcd; DCD-1; DCD_HUMAN; Dermcidin; DSEP; HCAP; PIF; Preproteolysin
Target Background
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms.
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