Recombinant Human Diacylglycerol kinase delta (DGKD), Truncated

Uniprot Id

Q16760

Target Species

Human

Target Name

DGKD

Target Full Name

Diacylglycerol kinase delta

Target Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.

Target Subcellular Location

Membrane, clathrin-coated pit. Cytoplasm.; [Isoform 1]: Cell membrane; Peripheral membrane protein. Cytoplasm.

Target Protein Families

Eukaryotic diacylglycerol kinase family

Target Tissue Specificity

[Isoform 2]: Widely expressed.; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen.

Target Synonyms

DGKD; KIAA0145Diacylglycerol kinase delta; DAG kinase delta; EC 2.7.1.107; 130 kDa diacylglycerol kinase; Diglyceride kinase delta; DGK-delta

Target Background

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.