Recombinant Human Diacylglycerol kinase iota (DGKI), Truncated

Uniprot Id

O75912

Target Species

Human

Target Name

DGKI

Target Full Name

Diacylglycerol kinase iota

Target Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position. By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression.

Target Subcellular Location

Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Cell junction, synapse, synaptic cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Nucleus.

Target Protein Families

Eukaryotic diacylglycerol kinase family

Target Tissue Specificity

Specifically expressed in brain and retina. In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum. Also detected in kidney.

Target Synonyms

DGKIDiacylglycerol kinase iota; DAG kinase iota; EC 2.7.1.107; Diglyceride kinase iota; DGK-iota