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| Cat.No | ACP09389 | Target Name | DHODH |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Mol Weight | 43.6kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q02127 |
|---|
Uniprot Id
Q02127
Target Species
Human
Target Name
DHODH
Target Full Name
Dihydroorotate dehydrogenase (quinone), mitochondrial
Target Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Target Involvement
Postaxial acrofacial dysostosis (POADS)
Target Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein.
Target Protein Families
Dihydroorotate dehydrogenase family, Type 2 subfamily
Target Research Area
Metabolism, Signal Transduction
Target Synonyms
DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; POADS; PYRD_HUMAN; URA1
Target Background
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
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