Recombinant Human Dipeptidyl aminopeptidase-like protein 6 (DPP6), Truncated

Uniprot Id

P42658

Target Species

Human

Target Name

DPP6

Target Full Name

A-type potassium channel modulatory protein DPP6

Target Function

Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity.

Target Involvement

Familial paroxysmal ventricular fibrillation 2 (VF2); Mental retardation, autosomal dominant 33 (MRD33)

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Target Protein Families

Peptidase S9B family

Target Tissue Specificity

Expressed predominantly in brain.

Target Synonyms

DPP6Dipeptidyl aminopeptidase-like protein 6; DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI; DPP VI

Target Background

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants.