Recombinant Human Dipeptidyl peptidase 8 (DPP8), Truncated

Uniprot Id

Q6V1X1

Target Species

Human

Target Name

DPP8

Target Full Name

Dipeptidyl peptidase 8

Target Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Peptidase S9B family, DPPIV subfamily

Target Tissue Specificity

Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.

Target Synonyms

Dipeptidyl peptidase 8; Dipeptidyl peptidase IV-related protein 1; Dipeptidyl peptidase VIII; Dipeptidylpeptidase 8; DP8; DPP VIII; Dpp8; DPP8_HUMAN; DPRP-1; DPRP1; EC 3.4.14.5; MSTP141; Prolyl dipeptidase DPP8

Target Background

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.