Recombinant Human Diphosphoinositol polyphosphate phosphohydrolase 1 (NUDT3)

Uniprot Id

O95989

Target Species

Human

Target Name

NUDT3

Target Full Name

Diphosphoinositol polyphosphate phosphohydrolase 1

Target Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility

Target Subcellular Location

Cytoplasm.

Target Protein Families

Nudix hydrolase family, DIPP subfamily

Target Tissue Specificity

Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.

Target Synonyms

5''''-P1; Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1; Diadenosine 5''; Diphosphoinositol polyphosphate phosphohydrolase 1; Diphosphoinositol polyphosphate phosphohydrolase; DIPP 1; DIPP; DIPP-1; DIPP1; Nucleoside diphosphate linked moiety X motif 3; Nucleoside diphosphate-linked moiety X motif 3; Nudix (nucleoside diphosphate linked moiety X) type motif 3; Nudix motif 3; Nudix type motif 3; NUDT 3; Nudt3; NUDT3_HUMAN; P6-hexaphosphate hydrolase 1