Recombinant Human DNA-directed RNA polymerase III subunit RPC9 (CRCP)

Uniprot Id

O75575

Target Species

Human

Target Name

CRCP

Target Full Name

DNA-directed RNA polymerase III subunit RPC9

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Target Subcellular Location

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Eukaryotic RPC9 RNA polymerase subunit family

Target Tissue Specificity

Ubiquitous. Most prevalent in testis.

Target Synonyms

Calcitonin gene related peptide receptor component; Calcitonin gene related peptide receptor component protein; Calcitonin gene-related peptide-receptor component protein; CGRP receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; CRCP; DNA-directed RNA polymerase III subunit RPC9; HsC17; RCP; RCP9 ; RNA polymerase III subunit C9; RPC9_HUMAN

Target Background

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.