Recombinant Human DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

Uniprot Id

P19388

Target Species

Human

Target Name

POLR2E

Target Full Name

DNA-directed RNA polymerases I, II, and III subunit RPABC1

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.

Target Subcellular Location

Nucleus.

Target Protein Families

Archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family

Target Synonyms

and III subunit ABC1; and III subunit RPABC1; DNA directed RNA polymerase II 23 kda polypeptide; DNA directed RNA polymerase II 23 kDa polypeptide; DNA directed RNA polymerase II polypeptide E; DNA directed RNA polymerase II subunit E; DNA directed RNA polymerases I II and III subunit RPABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I; hRPB25; hsRPB5; II; Polr2e; Polymerase (RNA) II (DNA directed) polypeptide E (25kD); Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; RNA polymerases I; RNA polymerases I, II, and III subunit ABC1; RPAB1_HUMAN; RPABC1; RPB5; RPB5 homolog; XAP4

Target Background

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene.