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| Cat.No | ACP14241 | Target Name | HELB |
|---|---|---|---|
| Target Synonyms | DNA helicase B; hDHB; helB; HELB_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NG08 |
|---|
Uniprot Id
Q8NG08
Target Species
Human
Target Name
HELB
Target Full Name
DNA helicase B
Target Function
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress
Target Subcellular Location
Nucleus. Cytoplasm. Chromosome.
Target Protein Families
RecD family, HELB subfamily
Target Tissue Specificity
Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain.
Target Synonyms
DNA helicase B; hDHB; helB; HELB_HUMAN
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