Recombinant Human DNA polymerase alpha catalytic subunit (POLA1), Truncated

Cat.No	ACP22309	Target Name	POLA1
Target Synonyms	alpha (70kD), alpha 1, catalytic subunit; Polymerase (DNA-directed)	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP22309

Target Name

POLA1

Target Synonyms

alpha (70kD), alpha 1, catalytic subunit; Polymerase (DNA-directed)

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P09884

Background Information

Uniprot Id

P09884
Target Species

Human
Target Name

POLA1
Target Full Name

DNA polymerase alpha catalytic subunit
Target Function

Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses.
Target Involvement

Pigmentary disorder, reticulate, with systemic manifestations, X-linked (PDR)
Target Subcellular Location

Nucleus. Cytoplasm, cytosol.
Target Protein Families

DNA polymerase type-B family
Target Synonyms

DKFZp686K1672; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DPOLA_HUMAN; OTTHUMP00000023089; OTTHUMP00000023090; P180; p180 subunit; POLA; POLA1; Polymerase (DNA directed), alpha 1, catalytic subunit; Polymerase (DNA-directed), alpha (70kD)

Recombinant Human DNA polymerase alpha catalytic subunit (POLA1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human DNA polymerase alpha catalytic subunit (POLA1), Truncated Now

Related Products