Recombinant Human DNA polymerase epsilon subunit 3 (POLE3)

Uniprot Id

Q9NRF9

Target Species

Human

Target Name

POLE3

Target Full Name

DNA polymerase epsilon subunit 3

Target Function

Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Target Synonyms

Arsenic transactivated protein; Arsenic-transactivated protein; ASTP; CHARAC 17; CHARAC17; CHRAC 17 ; CHRAC-17; CHRAC17; Chromatin Accessibility Complex 17; Chromatin accessibility complex 17 kDa protein; DNA Polymerase Epsilon p17 Subunit; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase II subunit 3; DPOE3_HUMAN; Histone fold protein CHRAC17; HuCHRAC 17; HuCHRAC17; p17; p17 subunit; POL E3; POLE 3; POLE3; Polymerase (DNA directed) epsilon 3; YBL 1; YBL1

Target Background

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.