Recombinant Human DnaJ homolog subfamily C member 5 (DNAJC5),Biotinylated

Uniprot Id

Q9H3Z4

Target Species

Human

Target Name

DNAJC5

Target Full Name

DnaJ homolog subfamily C member 5

Target Function

Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.

Target Involvement

Ceroid lipofuscinosis, neuronal, 4B (CLN4B)

Target Subcellular Location

Cytoplasm, cytosol. Membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane. Melanosome. Cell membrane.

Target Tissue Specificity

Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.

Target Research Area

Neuroscience

Target Synonyms

CLN 4; CLN4; CLN4B; CSP; cysteine string protein alpha; Cysteine string protein; DJC5; DnaJ (Hsp40) homolog subfamily C member 5; DnaJ homolog subfamily C member 5; DNAJC 5; Dnajc5; DNAJC5A; DNJC5_HUMAN; NCL

Target Background

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8.