Recombinant Human Docking protein 5 (DOK5)

Uniprot Id

Q9P104

Target Species

Human

Target Name

DOK5

Target Full Name

Docking protein 5

Target Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Target Protein Families

DOK family, Type B subfamily

Target Tissue Specificity

Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.

Target Research Area

Signal Transduction

Target Synonyms

chromosome 20 open reading frame 180; Docking protein 5; DOK 5; DOK5; DOK5 protein; DOK5_HUMAN; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; IRS6

Target Background

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.