Recombinant Human Double-stranded RNA-binding protein Staufen homolog 2 (STAU2)

Uniprot Id

Q9NUL3

Target Species

Human

Target Name

STAU2

Target Full Name

Double-stranded RNA-binding protein Staufen homolog 2

Target Function

RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.

Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum.

Target Synonyms

39K2; 39K3; DKFZp781K0371; Double stranded RNA binding protein Staufen homolog 2; Double-stranded RNA-binding protein Staufen homolog 2; MGC119606; STAU 2; stau2; STAU2_HUMAN; Staufen (Drosophila; RNA-binding protein) homolog 2; Staufen double-stranded RNA binding protein 2; Staufen homolog 2; Staufen RNA binding protein homolog 2; Staufen; RNA binding protein; homolog 2 (Drosophila)

Target Background

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.