Recombinant Human Dual specificity testis-specific protein kinase 2 (TESK2)

Uniprot Id

Q96S53

Target Species

Human

Target Name

TESK2

Target Full Name

Dual specificity testis-specific protein kinase 2

Target Function

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Target Subcellular Location

Nucleus.

Target Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family

Target Tissue Specificity

Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.

Target Synonyms

Dual specificity testis specific protein kinase 2; Dual specificity testis-specific protein kinase 2; MGC29168; OTTHUMP00000009093; RP23-109A3.2; Tesk2; TESK2_HUMAN; Testicular protein kinase 2; Testis specific kinase 2

Target Background

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants.