Recombinant Human Dystrobrevin alpha (DTNA)

Cat.No	ACP09693	Target Name	DTNA
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-743	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09693

Target Name

DTNA

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-743

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y4J8

Background Information

Uniprot Id

Q9Y4J8
Target Species

Human
Target Name

DTNA
Target Full Name

Dystrobrevin alpha
Target Function

May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
Target Involvement

Left ventricular non-compaction 1 (LVNC1)
Target Subcellular Location

Cytoplasm. Cell junction, synapse. Cell membrane.
Target Protein Families

Dystrophin family, Dystrobrevin subfamily
Target Tissue Specificity

Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
Target Synonyms

Alpha-dystrobrevin; D18S892E; DRP3; DTN; DTN-A; DTNA; DTNA_HUMAN; Dystrobrevin alpha; Dystrophin related protein 3; Dystrophin-related protein 3; FLJ96209; LVNC1; OTTHUMP00000163151; OTTHUMP00000163152; OTTHUMP00000163153; OTTHUMP00000163154; OTTHUMP00000163155
Target Background

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Recombinant Human Dystrobrevin alpha (DTNA)

Specifications

Immunogen Information

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