Recombinant Human Dystrobrevin beta (DTNB)

Uniprot Id

O60941

Target Species

Human

Target Name

DTNB

Target Full Name

Dystrobrevin beta

Target Function

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.

Target Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Basal cell membrane. Cell junction, synapse, postsynapse. Nucleus.

Target Protein Families

Dystrophin family, Dystrobrevin subfamily

Target Tissue Specificity

Highly expressed in brain, kidney and pancreas.

Target Synonyms

Beta dystrobrevin; Beta-dystrobrevin; DTN B; DTN-B; Dtnb; DTNB_HUMAN; Dystrobrevin beta; MGC17163; MGC57126

Target Background

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.