Recombinant Human E3 ubiquitin-protein ligase NRDP1 (RNF41)

Uniprot Id

Q9H4P4

Target Species

Human

Target Name

RNF41

Target Full Name

E3 ubiquitin-protein ligase NRDP1

Target Function

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control.

Target Tissue Specificity

Detected in ovary, testis and prostate.

Target Research Area

Cell Biology

Target Synonyms

4930511A05Rik; 4933415P08Rik; E3 ubiquitin protein ligase NRDP1; E3 ubiquitin-protein ligase NRDP1; Fetal Liver RING finger protein; FLRF; MGC45228; Neuregulin receptor degradation protein 1; NRDP1; RING finger protein 41; rnf41; RNF41_HUMAN; SBBI03