Recombinant Human E3 ubiquitin-protein ligase RNF144B (RNF144B), Truncated

Uniprot Id

Q7Z419

Target Species

Human

Target Name

RNF144B

Target Full Name

E3 ubiquitin-protein ligase RNF144B

Target Function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Target Subcellular Location

Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.

Target Protein Families

RBR family, RNF144 subfamily

Target Tissue Specificity

Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.

Target Synonyms

RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein

Target Background

Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane.