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| Cat.No | ACP00646 | Target Name | RNF182 |
|---|---|---|---|
| Target Synonyms | RING finger protein 182;RING-type E3 ubiquitin transferase RNF182 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 1-183aa |
| Mol Weight | 22.2 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N6D2 |
|---|
Uniprot Id
Q8N6D2
Target Species
Human
Target Name
RNF182
Target Full Name
E3 ubiquitin-protein ligase RNF182
Target Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cytoplasm.
Target Tissue Specificity
Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains. Highly expressed in innate immune organs such as lymph nodes and spleen
Target Research Area
Cell Biology
Target Synonyms
RNF182; E3 ubiquitin-protein ligase RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182
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