Recombinant Human Engulfment and cell motility protein 2 (ELMO2)

Uniprot Id

Q96JJ3

Target Species

Human

Target Name

ELMO2

Target Full Name

Engulfment and cell motility protein 2

Target Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Target Involvement

Vascular malformation, primary intraosseous (VMOS)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytosol. Membrane.

Target Tissue Specificity

Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.

Target Synonyms

CED 12; Ced 12 homolog 2; CED 12 homolog A; CED 12A; CED-12; ced-12 homolog 2; CED12; CED12 homolog A; CED12; C. elegans; homolog of; 2; CED12A; ELMO 2; ELMO-2; ELMO2; ELMO2_HUMAN; Engulfment and cell motility 2 (ced 12 homolog; C. elegans); Engulfment and cell motility 2; Engulfment and cell motility gene 2; Engulfment and cell motility protein 2; FLJ11656; hCED 12A; hCED-12A; hCED12A; KIAA1834; OTTHUMP00000031762; PH domain protein CED12A; Protein ced 12 homolog A; Protein ced-12 homolog A

Target Background

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants.