Recombinant Human Epithelial membrane protein 2 (EMP2), Truncated

Cat.No	ACP06916	Target Name	EMP2
Target Synonyms	EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06916

Target Name

EMP2

Target Synonyms

EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P54851

Background Information

Uniprot Id

P54851
Target Species

Human
Target Name

EMP2
Target Full Name

Epithelial membrane protein 2
Target Function

Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity. Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion. Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation. Regulates cell migration and cell contraction through PTK2 and SRC activation. Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation. Plays a role during cell death and cell blebbing. Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway. Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3. May play a role in glomerular filtration.
Target Involvement

Nephrotic syndrome 10 (NPHS10)
Target Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane. Apical cell membrane. Membrane raft. Cytoplasm. Nucleus.
Target Protein Families

PMP-22/EMP/MP20 family
Target Tissue Specificity

Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level).
Target Synonyms

EMP2; XMP; Epithelial membrane protein 2; EMP-2; Protein XMP

Recombinant Human Epithelial membrane protein 2 (EMP2), Truncated

Specifications

Immunogen Information

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