Recombinant Human ETS domain-containing protein Elk-1 (ELK1)

Uniprot Id

P19419

Target Species

Human

Target Name

ELK1

Target Full Name

ETS domain-containing protein Elk-1

Target Function

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation.

Target Subcellular Location

Nucleus.

Target Protein Families

ETS family

Target Tissue Specificity

Lung and testis.

Target Synonyms

ELK 1; Elk1; ELK1 member of ETS oncogene family; ELK1 protein; ELK1; ETS transcription factor; ELK1_HUMAN; ELK2 member of ETS oncogene family; ETS domain containing protein Elk 1; ETS domain containing protein Elk1; ETS domain protein Elk1; ETS domain-containing protein Elk-1; ETS like gene 1; Member of ETS oncogene family; Oncogene Elk1; Tyrosine kinase (ELK1) oncogene

Target Background

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.