Recombinant Human ETS translocation variant 4 (ETV4)

Uniprot Id

P43268

Target Species

Human

Target Name

ETV4

Target Full Name

ETS translocation variant 4

Target Function

Transcriptional activator. May play a role in keratinocyte differentiation.; (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'.

Target Subcellular Location

Nucleus.

Target Protein Families

ETS family

Target Tissue Specificity

Expressed in keratinocytes.

Target Synonyms

Adenovirus E1A enhancer binding protein; Adenovirus E1A enhancer-binding protein; E1A F; E1A-F; ETS translocation variant 4; ets variant gene 4 (E1A enhancer binding protein E1AF); ETV4; ETV4_HUMAN; PEA3; PEA3 protein; PEAS3; Polyomavirus enhancer activator 3; Polyomavirus enhancer activator 3 homolog; Protein PEA3

Target Background

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in chromosome and nucleolus.