Recombinant Human Exosome complex component RRP43 (EXOSC8)

Uniprot Id

Q96B26

Target Species

Human

Target Name

EXOSC8

Target Full Name

Exosome complex component RRP43

Target Function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

Target Involvement

Pontocerebellar hypoplasia 1C (PCH1C)

Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, nucleolus.

Target Protein Families

RNase PH family

Target Synonyms

bA421P11.3; CBP interacting protein 3; CIP3; EAP2; EC 3.1.13; EXOS8_HUMAN; EXOSC8; Exosome complex component RRP43; Exosome complex exonuclease RRP43; Exosome component 8; OIP-2; OIP2; Opa interacting protein 2 ; Opa-interacting protein 2; OTTHUMP00000042274; p9; Ribosomal RNA processing protein 43; Ribosomal RNA processing protein 43; S. cerevisiae; homolog of; Ribosomal RNA-processing protein 43; RP11 421P11.3 ; RRP43; Rrp43p

Target Background

This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6.