Recombinant Human Extracellular matrix protein 1 (ECM1)

Uniprot Id

Q16610

Target Species

Human

Target Name

ECM1

Target Full Name

Extracellular matrix protein 1

Target Function

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.

Target Involvement

Lipoid proteinosis (LiP)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.

Target Research Area

Immunology

Target Synonyms

ECM 1; Ecm1; ECM1_HUMAN; Extracellular matrix protein 1; Secretory component p85; URBWD

Target Background

This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.