Recombinant Human F-box only protein 22 (FBXO22)

Uniprot Id

Q8NEZ5

Target Species

Human

Target Name

FBXO22

Target Full Name

F-box only protein 22

Target Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Target Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line.

Target Tissue Specificity

Predominantly expressed in liver, also enriched in cardiac muscle.

Target Research Area

Cell Biology

Target Synonyms

0610033L19Rik; 1600016C16Rik; F box only protein 22; F box protein 22; F box protein FBX22p44 ; F-box only protein 22; F-box protein FBX22p44; FBX22; FBX22_HUMAN; FBXO 22; FBXO22; FIST domain containing 1; FISTC1; FLJ13986; MGC124731; MGC31799

Target Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.