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| Cat.No | ACP16456 | Target Name | FBXO38 |
|---|---|---|---|
| Target Synonyms | FBXO38; SP329F-box only protein 38 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6PIJ6 |
|---|
Uniprot Id
Q6PIJ6
Target Species
Human
Target Name
FBXO38
Target Full Name
F-box only protein 38
Target Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination.
Target Involvement
Neuronopathy, distal hereditary motor, 2D (HMN2D)
Target Subcellular Location
Cytoplasm, cytosol. Nucleus.
Target Synonyms
FBXO38; SP329F-box only protein 38
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