Recombinant Human Fanconi anemia group E protein (FANCE)

Uniprot Id

Q9HB96

Target Species

Human

Target Name

FANCE

Target Full Name

Fanconi anemia group E protein

Target Function

As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.

Target Involvement

Fanconi anemia complementation group E (FANCE)

Target Subcellular Location

Nucleus.

Target Synonyms

2810451D06Rik; AI415634; AW209126; FACE; FAE; FANCE; FANCE_HUMAN; Fanconi anemia complementation group E; Fanconi anemia group E protein; OTTHUMP00000016254; Protein FACE; RGD1561045

Target Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E.