Recombinant Human FAS-associated factor 1 (FAF1)

Uniprot Id

Q9UNN5

Target Species

Human

Target Name

FAF1

Target Full Name

FAS-associated factor 1

Target Function

Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

Target Synonyms

CGI 03; FAF1; FAF1 protein; FAF1_HUMAN; Fas (TNFRSF6) associated factor 1; FAS associated factor 1; Fas associated protein factor 1; FAS-associated factor 1; FLJ37524; hFAF1; HFAF1s; Protein FAF1; TNFRSF6 associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A

Target Background

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.