Recombinant Human Fibroblast growth factor-binding protein 1 (FGFBP1)

Uniprot Id

Q14512

Target Species

Human

Target Name

FGFBP1

Target Full Name

Fibroblast growth factor-binding protein 1

Target Function

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Target Subcellular Location

Secreted, extracellular space. Cell membrane; Peripheral membrane protein.

Target Protein Families

Fibroblast growth factor-binding protein family

Target Tissue Specificity

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carc

Target Synonyms

17 kDa HBGF-binding protein; 17 kDa heparin binding growth factor binding protein ; 17 kDa heparin-binding growth factor-binding protein; FGF binding protein 1; FGF BP ; FGF BP1; FGF-binding protein 1; FGF-BP; FGF-BP1; FGFBP ; FGFBP-1; Fgfbp1; FGFP1_HUMAN; Fibroblast growth factor binding protein 1 precursor; Fibroblast growth factor-binding protein 1; HBp17

Target Background

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.